Rs5558

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is asnp
is mentioned by
dbSNPrs5558
nextbiors5558
hapmaprs5558
1000 genomesrs5558
hgdprs5558
ensemblrs5558
gopubmedrs5558
scholarrs5558
googlers5558
pharmgkbrs5558
gwascentralrs5558
openSNPrs5558
23andMers5558
23andMe allrs5558
SNP Nexus

SNPshotrs5558
SNPdbers5558
MSV3drs5558
GeneSLC6A2
Chromosome16
Orientationplus
Position55733559
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) 0
(G;G) None
(T;G) None
(T;T) 0 normal
Make rs5558(G;T)
? (G;G) (G;T) (T;T) 28
rs5558 (F528C) is a non-synonymous SNP in SLC6A2 (norepinephrine transporter), with a T encoding for Phenylalanine and C encoding the rare Cysteine variant.

[PMID 19105200] assoc. w/ major depression

[PMID 15894713] Cysteine variant exhibited increased norepinephrine transport, insensitivity to protein kinase C induced down-regulation, and a decrease in desipramine (tricyclic antidepressant) potency

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