Rs543749
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs543749 |
| hapmap | rs543749 |
| hgdp | rs543749 |
| ensembl | rs543749 |
| gopubmed | rs543749 |
| scholar | rs543749 |
| rs543749 | |
| pharmgkb | rs543749 |
| hgvbaseg2p | rs543749 |
| medrefsnp | rs543749 |
| 23andMe | rs543749 |
| SNP Nexus |
| Gene | ADAM33 |
| Chromosome | 20 |
| Orientation | plus |
| Position | 3597678 |
| Genotype | Effect |
|---|---|
| rs543749(G;G) | if a smoker, somewhat more likely to develop COPD |
| rs543749(G;T)* | ? |
| rs543749(T;T)* | ? |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs543749(G;G) | 2.12.1 | if a smoker, somewhat more likely to develop COPD |
A study of ~600 non-Hispanic white males who smoked concluded that rs543749(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs543749(T) alleles.10.1186/1465-9921-10-21
