From SNPedia
| Geno
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Mag
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Summary
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| (G;G)
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2.1
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if a smoker, somewhat more likely to develop COPD
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rs543749, also known as IVS21_22 or V-1, is a SNP in the ADAM metallopeptidase domain 33
ADAM33 gene.
A study of ~600 non-Hispanic white males who smoked concluded that rs543749(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs543749(T) alleles.10.1186/1465-9921-10-21
