From SNPedia
The association between type-1 diabetes and rs5215 is mentioned as being replicated in [PMID 17554300]; there is also a 90% correlation between rs5215 and rs5219.
| ? | (C;C) (C;T) (T;T) |
|---|
 |
| Venter snp
|
| Source
| plos
|
| Gene
| KCNJ11
|
| allele
| T
|
| frequency
| 0.592
|
| sift
| TOLERATED
|
| HuRef
| 1103649619608
|
| Disease Association
| Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as type II diabetes mellitus.
|
| GWAS snp
|
| PMID
| [PMID 18372903]
|
| Trait
| Type 2 diabetes
|
| Title
| Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
|
| Risk Allele
| C
|
| P-val
| 3.9999999999999998E-7
|
| Odds Ratio
| 1.16 [1.09-1.23]
|
| GWAS snp
|
| PMID
| [PMID 17463249]
|
| Trait
| Type 2 diabetes
|
| Title
| Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
|
| Risk Allele
| C
|
| P-val
| 5.0000000000000002E-11
|
| Odds Ratio
| 1.14 [1.10-1.19]
|
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
