Rs521102

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Orientationminus
is asnp
is mentioned by
dbSNPrs521102
PheGenIrs521102
nextbiors521102
hapmaprs521102
1000 genomesrs521102
hgdprs521102
ensemblrs521102
gopubmedrs521102
geneviewrs521102
scholarrs521102
googlers521102
pharmgkbrs521102
gwascentralrs521102
openSNPrs521102
23andMers521102
23andMe allrs521102
SNP Nexus

SNPshotrs521102
SNPdbers521102
MSV3drs521102
GeneCHEK1
Chromosome11
Orientationminus
GMAF0.4325
Position125514573
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(C;C) 0 normal
(C;T) 0 normal
(T;T) pancreatic cancer patients respond poorer to combined therapy
? (C;C) (C;T) (T;T) 28
rs521102, also known as IVS11 +35, G>A, is a SNP in the CHEK1 gene.

In a study of 119 American patients with potentially resectable pancreatic cancer, the rs521102(T) allele was associated with poorer overall survival (ie response) to combined gerncitabine radiation therapy. Also, as 1 of 3 SNPs its risk allele is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy; median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004). [PMID 18381943OA-icon.png]