From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
2.5x increased risk of Azheimer's and decreased age at onset
|
| (A;G)
|
|
None
|
| (G;G)
|
|
None
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
increases susceptibility to
Alzheimer's disease 2.56 times for (A;A) homozygotes [
PMID 10976648]
[PMID 18855268] systolic blood pressure increased with rs4934(A)
| Venter snp
|
| Source
|
plos
|
| Gene
|
SERPINA3
|
| allele
|
A
|
| frequency
|
0.492
|
| sift
|
TOLERATED
|
| HuRef
|
1103649133833
|
| Disease Association
|
Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) (MIM:107280).
|
[PMID 21067581] finds no association between rs4934 and pulmonary emphysema
[PMID 19907165] Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population
