From SNPedia
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
This SNP, located in an intron of the
GRIA3 gene (also known as AMPA3), has been linked in one study to increased thoughts of
suicide in patients taking the anti-depressant drug
citalopram. The increased risk is calculated to be 1.9x. If the individual is also carrying two
rs2518224(C) alleles, i.e. is a
rs2518224(C;C) homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [
PMID 17898344]
| PharmGKB | PA162263538 |
| Name | |
| Annotation | This SNP in the GRIA3 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped. |
| Gene | GRIA3 |
| Featue | |
| Evidence | PubMed ID:17898344 |
| Drugs | citalopram |
| Diseases | Depression |
| Curation Level | Curated |
