Rs4825476

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Orientationplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 0 normal
(G;G) 2
(T;T) 0
ReferenceGRCh38 38.1/141
ChromosomeX
Position123307628
GeneGRIA3
is asnp
is mentioned by
dbSNPrs4825476
Exacrs4825476
PheGenIrs4825476
nextbiors4825476
hapmaprs4825476
1000 genomesrs4825476
hgdprs4825476
ensemblrs4825476
gopubmedrs4825476
geneviewrs4825476
scholarrs4825476
googlers4825476
pharmgkbrs4825476
gwascentralrs4825476
openSNPrs4825476
23andMers4825476
23andMe allrs4825476
SNP Nexus

SNPshotrs4825476
SNPdbers4825476
MSV3drs4825476
GMAF0.3392
Max Magnitude2
? (A;A) (A;G) (G;G) 28
This SNP, located in an intron of the GRIA3 gene (also known as AMPA3), has been linked in one study to increased thoughts of suicide in patients taking the anti-depressant drug citalopram. The increased risk is calculated to be 1.9x. If the individual is also carrying two rs2518224(C) alleles, i.e. is a rs2518224(C;C) homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [PMID 17898344]



[PMID 19724244OA-icon.png] Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.


[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.


GET Evidence
rs4825476
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.619565
summary



[PMID 23337130] Common genetic background in anorexia nervosa and obsessive compulsive disorder: preliminary results from an association study.