| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
This SNP, located in an intron of the
GRIA3 gene (also known as AMPA3), has been linked in one study to increased thoughts of
suicide in patients taking the anti-depressant drug
citalopram. The increased risk is calculated to be 1.9x. If the individual is also carrying two
rs2518224(C) alleles, i.e. is a
rs2518224(C;C) homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [
PMID 17898344]
[PMID 19724244] Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
| GET Evidence
|
| rs4825476
|
| aa_change
|
|
| aa_change_short
|
|
| impact
|
pharmacogenetic
|
| qualified_impact
|
Insufficiently evaluated pharmacogenetic
|
| overall_frequency
|
0.619565
|
| summary
|
|
