rs4779584

plus

Geno	Mag	Summary
(C;C)	0	average
(C;T)	2	1.23x risk for colorectal cancer
(T;T)	2	1.70x risk for colorectal cancer

Reference

GRCh38 38.1/141

Chromosome

15

Position

32702555

is a	snp
is	mentioned by
dbSNP	rs4779584
dbSNP (classic)	rs4779584
ClinGen	rs4779584
ebi	rs4779584
HLI	rs4779584
Exac	rs4779584
Gnomad	rs4779584
Varsome	rs4779584
LitVar	rs4779584
Map	rs4779584
PheGenI	rs4779584
Biobank	rs4779584
1000 genomes	rs4779584
hgdp	rs4779584
ensembl	rs4779584
geneview	rs4779584
scholar	rs4779584
google	rs4779584
pharmgkb	rs4779584
gwascentral	rs4779584
openSNP	rs4779584
23andMe	rs4779584
SNPshot	rs4779584
SNPdbe	rs4779584
MSV3d	rs4779584
GWAS Ctlg	rs4779584

GMAF

0.4578

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

A study of 7000+ UK patients with colorectal cancer identified two SNPs that increase disease risk, one of which is rs4779584. Inheriting the rs4779584(T) risk allele is estimated to increase overall risk odds by 1.26x (CI: 1.19-1.34, p=4x10e-14). When analyzing data between genotypes, the odds ratios reported for heterozygotes was 1.23x (CI:1.13-1.33), and for rs4779584(T;T) homozygotes, 1.70 (CI: 1.41-2.04).[PMID 18084292]

Inheriting the risk variant at both SNP loci (i.e. rs4779584 and rs6983267) is estimated to increase the overall risk of developing colorectal cancer about 3 fold. The authors of this study are quoted as saying that "the lifetime risk [of bowel cancer] is about 5% in the UK so it's going up to 7% or so if you've got both bad copies of a variant." nature

This SNP has also been associated with increased colorectal cancer risk in a French study of 1,000+ patients.10.1038/ejhg.2015.72

GWAS snp
PMID	[PMID 18372905]
Trait	Colorectal cancer
Title	A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3
Risk Allele
P-val	4.9999999999999998E-7
Odds Ratio	1.23 [1.14-1.34]

OMIM	601228
Desc	POLYPOSIS SYNDROME, HEREDITARY MIXED, 1; HMPS1
Variant
Related	also

[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort

[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome

[PMID 21119214 ] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters

[PMID 21179028 ] Replication study of SNP associations for colorectal cancer in Hong Kong Chinese

[PMID 21655089 ] Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

GWAS snp
PMID	[PMID 21761138 ]
Trait
Title	Meta-analysis of new genome-wide association studies of colorectal cancer risk.
Risk Allele
P-val	2E-8
Odds Ratio	1.1800 [1.11-1.24]

[PMID 22367214 ] Characterization of gene-environment interactions for colorectal cancer susceptibility loci

[PMID 19011631 ] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

[PMID 20437058 ] The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.

[PMID 20501757 ] Low-penetrance susceptibility variants in familial colorectal cancer.

[PMID 20648012 ] Association studies on 11 published colorectal cancer risk loci.

[PMID 21071539 ] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

[PMID 21314996 ] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

[PMID 21402474] GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.

[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.

GWAS snp
PMID	[PMID 23266556 ]
Trait	Colorectal cancer
Title	Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis.
Risk Allele
P-val	5E-7
Odds Ratio	1.12 [1.08-1.19]

[PMID 23875689] Colorectal Cancer-Susceptibility Single Nucleotide Polymorphisms in Korean Population

[PMID 22848671 ] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

[PMID 22999960 ] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

[PMID 23434150 ] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?

[PMID 24753543 ] Shared and Independent Colorectal Cancer Risk Alleles in TGFβ-related Genes in African and European Americans

[PMID 25873010 ] Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

[PMID 27769063 ] Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.

[PMID 28849422] The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese.

[PMID 33476087 ] SNPs Associated with Colorectal Cancer at 15q13.3 Affect Risk Enhancers that Modulate GREM1 Gene Expression.