Rs4570625(G;G)
From SNPedia
| higher scores on anxiety-related personality traits; greater placebo response |
| Is a | genotype |
| of | rs4570625 |
| Gene | TPH2 |
| Chromosome | 12 |
| Position | 72,331,923 |
| mentioned | by |
| Magnitude | 1.9 |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 1.9 | higher scores on anxiety-related personality traits; greater placebo response |
| (G;T) | normal | |
| (T;T) | 0 | normal |
One study of 25 people [PMID 19052197] shows this genotype was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.
This SNP has been linked to several psychiatric and/or behavioral phenomena, including:
- higher scores on anxiety-related personality traits
- obsessive compulsive disorder
- panic disorder with a possible gender-dependent effect
