Rs4464148

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is asnp
is mentioned by
dbSNPrs4464148
hapmaprs4464148
hgdprs4464148
ensemblrs4464148
gopubmedrs4464148
scholarrs4464148
googlers4464148
pharmgkbrs4464148
hgvbaseg2prs4464148
medrefsnprs4464148
23andMers4464148
SNP Nexus

GeneSMAD7
Chromosome18
Orientationplus
Position44713029
GenotypeEffect
rs4464148(C;C)1.35x increased risk for colorectal cancer
rs4464148(C;T)1.10x increased risk for colorectal cancer
rs4464148(T;T)1x normal risk for colorectal cancer


Genotypes Magnitude Summary
Rs4464148(C;C) 1.35x increased risk for colorectal cancer
Rs4464148(C;T) 1.10x increased risk for colorectal cancer
Rs4464148(T;T) 1x normal risk for colorectal cancer
rs4464148 is one of 3 SNPs in the SMAD7 gene associated with risk for colorectal cancer, based on a large study (7,400+ cases) conducted in the UK. The odds ratios show an increased risk for the minor rs4464148(C) allele; the OR for (C;C) homozygotes is 1.35 (CI: 1.2-1.51), and for (C;T) heterozygotes 1.10 (CI: 1.09-1.21), overall p=7x10-8.[PMID 17934461]
? (C;C) (C;T) (T;T)


[PMID 20124488] Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7

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