From SNPedia
| Geno
|
Mag
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Summary
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| (C;C)
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1.35x increased risk for colorectal cancer
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| (C;T)
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1.10x increased risk for colorectal cancer
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| (T;T)
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1x normal risk for colorectal cancer
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| ? | (C;C) (C;T) (T;T) | 28 |
|---|
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is one of 3 SNPs in the
SMAD7 gene associated with risk for
colorectal cancer, based on a large study (7,400+ cases) conducted in the UK. The odds ratios show an increased risk for the minor
rs4464148(C) allele; the OR for (C;C) homozygotes is 1.35 (CI: 1.2-1.51), and for (C;T) heterozygotes 1.10 (CI: 1.09-1.21), overall p=7x10
-8.[
PMID 17934461]
[PMID 20124488] Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7
[PMID 21075068] SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study
[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
[PMID 21221812] A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population
[PMID 21910156] Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women
[PMID 22505654] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
