From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
4
|
17x increased myopathy risk for statin users
|
| (C;T)
|
2.1
|
4.5x increased myopathy risk for statin users
|
| (T;T)
|
0
|
normal
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
is a SNP in the
SLCO1B1 gene, a gene which encodes a protein involved in the liver's uptake of certain drugs, including the
statins used to lower cholesterol levels.
[PMID 18650507] rs4363657 in nearly complete linkage disequilibrium with rs4149056 SNP (r2=0.97), which has been linked to statin metabolism. rs4149056(C) odds ratio for myopathy among 20,000 individuals taking either 40 or 80mg of simvastatin daily was 4.5 (CI: 2.6-7.7) per copy of the C allele, and 16.9 (CI: 4.7-61.1) in (C;C) as compared with (T;T) homozygotes.
See also rs4149056 for a more detailed description of the effect of SLCO1B1 gene SNPs on the metabolism of many drugs.
| OMIM | 604843 |
| Desc | SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B1; SLCO1B1 |
| Variant | |
| Related | also |
[PMID 21646302] Mayo Genome Consortia: A Genotype-Phenotype Resource for Genome-Wide Association Studies With an Application to the Analysis of Circulating Bilirubin Levels
[PMID 21992719] SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group
