From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
>1.5x increased testicular cancer risk for men
|
| (C;T)
|
|
1.5x increased testicular cancer risk for men
|
| (T;T)
|
1.2
|
normal
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
Testicular germ cell tumor risk I("TGCT"; i.e.
testicular cancer risk) was increased 40% per copy of the major (T) allele at
rs4324715 and
rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4
SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. [doi|10.1038/ng.393]
