Rs4146894
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs4146894 |
| hapmap | rs4146894 |
| hgdp | rs4146894 |
| ensembl | rs4146894 |
| gopubmed | rs4146894 |
| scholar | rs4146894 |
| rs4146894 | |
| pharmgkb | rs4146894 |
| hgvbaseg2p | rs4146894 |
| medrefsnp | rs4146894 |
| 23andMe | rs4146894 |
| SNP Nexus |
| Gene | PLEKHA1 |
| Chromosome | 10 |
| Orientation | minus |
| Position | 124145370 |
| Genotype | Effect |
|---|---|
| rs4146894(A;A) | 9.1x risk for AMD |
| rs4146894(A;G) | 2.6x risk for AMD |
| rs4146894(G;G) | average |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs4146894(A;A) | 2.52.5 | 9.1x risk for AMD |
| Rs4146894(A;G) | 2.6x risk for AMD | |
| Rs4146894(G;G) | 00 | average |
rs4146894, a SNP in the PLEKHA1 gene, is associated with increased risk for age related macular degeneration based on a study of 118 Caucasians. The odds ratio for risk of AMD was 9.1 (CI: 4.0-20.9, p=0.0001) for the AA genotype and 2.6 (CI: 1.3-5.5, p=0.04) for the AG genotype. The risk is increased further by the status of two other chromosome 10 SNPs, rs10490924 and rs11200638. [PMID 18079691]
| ? | (A;A) (A;G) (G;G) |
|---|---|
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