From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2.1
|
9.1x risk for AMD, but replication is lacking
|
| (A;G)
|
|
2.6x risk for AMD
|
| (G;G)
|
0
|
average
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
, a SNP in the
PLEKHA1 gene, is associated with increased risk for
age related macular degeneration based on a study of 118 Caucasians. The odds ratio for risk of AMD was 9.1 (CI: 4.0-20.9, p=0.0001) for the AA genotype and 2.6 (CI: 1.3-5.5, p=0.04) for the AG genotype. The risk is increased further by the status of two other chromosome 10 SNPs,
rs10490924 and
rs11200638. [
PMID 18079691]
