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Rs3814570

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Orientationplus
is asnp
is mentioned by
dbSNPrs3814570
PheGenIrs3814570
nextbiors3814570
hapmaprs3814570
1000 genomesrs3814570
hgdprs3814570
ensemblrs3814570
gopubmedrs3814570
geneviewrs3814570
scholarrs3814570
googlers3814570
pharmgkbrs3814570
gwascentralrs3814570
openSNPrs3814570
23andMers3814570
23andMe allrs3814570
SNP Nexus

SNPshotrs3814570
SNPdbers3814570
MSV3drs3814570
GeneTCF7L2
Chromosome10
Orientationplus
GMAF0.1818
Position114708510
ReferenceGRCh37 37.1/131
Max Magnitude1.5
Geno Mag Summary
(C;C) 1 Normal risk of developing Crohn's disease
(C;T) 1.5 1.3x increased risk for Crohn's disease with ileal involvement
(T;T) 1.5 1.3x increased risk for Crohn's disease with ileal involvement
? (C;C) (C;T) (T;T) 28
rs3814570 is a SNP in the transcription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2 gene.

A study of 784 Crohn's disease patients with ileal involvement concluded that rs3814570 was associated with increased risk, but not with risk for colonic Crohn's disease or ulcerative colitis. The odds ratio was 1.27 (CI: 1.07 - 1.52, p = 0.00737).[PMID 19221600OA-icon.png]

[PMID 19351735OA-icon.png] Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.