Rs3740065

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Patients receiving tamoxifen have shorter recurrence-free survival
Orientationminus
is asnp
is mentioned by
dbSNPrs3740065
PheGenIrs3740065
hapmaprs3740065
1000 genomesrs3740065
hgdprs3740065
ensemblrs3740065
gopubmedrs3740065
geneviewrs3740065
scholarrs3740065
googlers3740065
pharmgkbrs3740065
gwascentralrs3740065
openSNPrs3740065
23andMers3740065
23andMe allrs3740065
SNP Nexus

SNPshotrs3740065
SNPdbers3740065
MSV3drs3740065
GeneABCC2
Chromosome10
Orientationminus
GMAF0.185
Position101605693
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs3740065(C;C)
Make rs3740065(C;T)
Make rs3740065(T;T)
? (C;C) (C;T) (T;T) 28
rs3740065 is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 gene.

A study of 282 hormone receptor-positive, invasive breast cancer Japanese patients receiving tamoxifen found a significant association with shorter recurrence-free survival (p = .00017; hazard ratio 10.64, CI: 1.44 - 78.88) in rs3740065(T;T) patients; the hazard ratio for carriers of one (T) allele was 3.5 (CI: 0.5-26).[PMID 20124171] Curiously, no significant difference in plasma levels of the tamoxifen metabolites endoxifen or 4-hydroxytamoxifen were seen.

This same study of tamoxifen users concluded that rs3740065(T;T) patients who also had two CYP2D6 risk alleles had a 45 fold higher risk of recurrence than patients with zero or one (out of the possible four) risk alleles. The overall average recurrence risk was 5x for carriers of a total of two risk alleles, and 20x for carriers of a total of three risk alleles.[PMID 20124171]

A nearby SNP, rs11190303, also showed significant association to recurrence-free survival; it was shown to be strongly linked to rs3740065 (r2 with LD of 0.79).[PMID 20124171]


[PMID 23222202] Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.