Rs34516635

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is asnp
is mentioned by
dbSNPrs34516635
hapmaprs34516635
hgdprs34516635
ensemblrs34516635
gopubmedrs34516635
scholarrs34516635
googlers34516635
pharmgkbrs34516635
hgvbaseg2prs34516635
medrefsnprs34516635
23andMers34516635
SNP Nexus

GeneIGF1R
Chromosome15
Orientationplus
Position97269498
GenotypeEffect
rs34516635(G;G)normal
rs34516635(A;G)longevity effect?
rs34516635(A;A)longevity effect?


Genotypes Magnitude Summary
Rs34516635(A;A) longevity effect?
Rs34516635(A;G) longevity effect?
Rs34516635(G;G) normal
rs34516635 is one of a small number of (rare) SNPs in the IGF1R gene found in a study of 384 Ashkenazi centenarians to potentially be associated with longevity. The rs34516635(A) allele was found somewhat more frequently (p=0.02) in female centenarians than in controls. No association was found for males. Higher IGF1 levels and an average decrease in maximal lifetime height of 2.5cm were also reported to be associated with (female Ashkenazi) centenarians.[PMID 18316725]
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