rs34516635

Longevity and height for Ashkenazi Jewish women.

plus

Geno	Mag	Summary
(A;A)	1.5	Possibly increased longevity for Ashkenazi Jewish women.
(A;G)	1.5	Possibly increased longevity for Ashkenazi Jewish women.
(G;G)	1.1	Less longevity for Ashkenazi Jewish women.

Reference

GRCh38 38.1/141

Chromosome

15

Position

98908747

Gene

IGF1R

is a	snp
is	mentioned by
dbSNP	rs34516635
dbSNP (classic)	rs34516635
ClinGen	rs34516635
ebi	rs34516635
HLI	rs34516635
Exac	rs34516635
Gnomad	rs34516635
Varsome	rs34516635
LitVar	rs34516635
Map	rs34516635
PheGenI	rs34516635
Biobank	rs34516635
1000 genomes	rs34516635
hgdp	rs34516635
ensembl	rs34516635
geneview	rs34516635
scholar	rs34516635
google	rs34516635
pharmgkb	rs34516635
gwascentral	rs34516635
openSNP	rs34516635
23andMe	rs34516635
SNPshot	rs34516635
SNPdbe	rs34516635
MSV3d	rs34516635
GWAS Ctlg	rs34516635

Max Magnitude

1.5

rs34516635 is one of a small number of (rare) SNPs in the IGF1R gene found in a study of 384 Ashkenazi centenarians to potentially be associated with longevity and ageing. The rs34516635(A) allele was found somewhat more frequently (p=0.02) in female centenarians than in controls. No association was found for males. Higher IGF1 levels and an average decrease in maximal lifetime height of 2.5cm were also reported to be associated with (female Ashkenazi) centenarians.[PMID 18316725 ]

[PMID 20625407 ] A comprehensive in silico analysis of the functional and structural impact of SNPs in the IGF1R gene.

ClinVar
Risk	Rs34516635(A;A)
Alt	Rs34516635(A;A)
Reference	Rs34516635(G;G)
Significance	Probable-non-pathogenic
Disease	not specified
Variation	info
Gene	IGF1R
CLNDBN	not specified
Reversed	0
HGVS	NC_000015.9:g.99451976G>A
CLNSRC	UniProtKB (protein)
CLNACC	RCV000179350.1,