Rs33949390
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs33949390 |
| hapmap | rs33949390 |
| hgdp | rs33949390 |
| ensembl | rs33949390 |
| gopubmed | rs33949390 |
| scholar | rs33949390 |
| rs33949390 | |
| pharmgkb | rs33949390 |
| hgvbaseg2p | rs33949390 |
| medrefsnp | rs33949390 |
| 23andMe | rs33949390 |
| SNP Nexus |
| Gene | LRRK2 |
| Chromosome | 12 |
| Orientation | plus |
| Position | 39000111 |
| Genotype | Effect |
|---|---|
| rs33949390(C;C) | 3.3x increased risk for Parkinson's disease |
| rs33949390(C;G) | 3.3x increased risk for Parkinson's disease |
| rs33949390(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs33949390(C;C) | 3.3x increased risk for Parkinson's disease | |
| Rs33949390(C;G) | 3.3x increased risk for Parkinson's disease | |
| Rs33949390(G;G) | 00 | normal |
Also known as R1628P, rs33949390 is a SNP in the LRRK2 gene.
A study of Chinese patients with Parkinson's disease concluded that in this population, after adjustments were made for age, age of onset, and gender, rs33949390(C) carriers were 3.3x more likely to develop the disease than noncarriers (CI: 1.4- 7.9, p = 0.007).[PMID 18781329]
| ? | (C;G) (G;G) |
|---|---|
|
| |
Related to LEUCINE-RICH REPEAT KINASE 2; LRRK2
according to omim 609007. See also
[PMID 19854095] The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population
