Rs324650
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs324650 |
| hapmap | rs324650 |
| hgdp | rs324650 |
| ensembl | rs324650 |
| gopubmed | rs324650 |
| scholar | rs324650 |
| rs324650 | |
| pharmgkb | rs324650 |
| hgvbaseg2p | rs324650 |
| medrefsnp | rs324650 |
| 23andMe | rs324650 |
| SNP Nexus |
| Gene | CHRM2 |
| Chromosome | 7 |
| Orientation | plus |
| Position | 136344200 |
| Genotype | Effect |
|---|---|
| rs324650(T;T) | |
| rs324650(A;T) | |
| rs324650(A;A) |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs324650(A;A) | 00 | |
| Rs324650(A;T) | 0.10.1 | |
| Rs324650(T;T) | 0.10.1 |
In 2009, a large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2 [PMID 19418213].
Earlier work had observed that this snp (and perhaps its neighbors) influenced intelligence and alcohol dependence
[PMID 16000316] CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. And the earlier [PMID 15229186]
[PMID 17160701] and [PMID 17081262] or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324640, showed similar results to rs324650, and was in linkage disequilibrium (r2 = 0.90) with it. [PMID 17081262].
| ? | (A;A) (A;T) (T;T) |
|---|---|
|
| |
[PMID 19644963] Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction
