Rs324640

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is asnp
is mentioned by
dbSNPrs324640
hapmaprs324640
hgdprs324640
ensemblrs324640
gopubmedrs324640
scholarrs324640
googlers324640
pharmgkbrs324640
hgvbaseg2prs324640
medrefsnprs324640
23andMers324640
SNP Nexus

GeneCHRM2
Chromosome7
Orientationplus
Position136339535
GenotypeEffect
rs324640(A;A)higher IQ
rs324640(A;G)somewhat higher IQ
rs324640(G;G)normal. rare for asians.


Genotypes Magnitude Summary
Rs324640(A;A) higher IQ
Rs324640(A;G) somewhat higher IQ
Rs324640(G;G) normal. rare for asians.
SNPs in the SNAP25 gene were initially [PMID 17160701] linked to intelligence but have failed to replicate [PMID 19418213].

While now suspect, the original work can be found in [PMID 17160701] and [PMID 17081262] or this pdf poster show association between the CHRM2 gene and intelligence . In this study of ~300 Caucasians, the (G;G) genotype appeared to typically have a 4 point higher IQ than the (A;G) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324650, showed similar results to rs324640, and was in linkage disequilibrium (r2 = 0.90) with it. [PMID 17081262]

? (A;A) (A;G) (G;G)


[PMID 18979273] Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction