Rs2811712
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs2811712 |
| hapmap | rs2811712 |
| hgdp | rs2811712 |
| ensembl | rs2811712 |
| gopubmed | rs2811712 |
| scholar | rs2811712 |
| rs2811712 | |
| pharmgkb | rs2811712 |
| hgvbaseg2p | rs2811712 |
| medrefsnp | rs2811712 |
| 23andMe | rs2811712 |
| SNP Nexus |
| Chromosome | 9 |
| Orientation | plus |
| Position | 21988034 |
| Genotype | Effect |
|---|---|
| rs2811712(G;G) | >1.5x less risk for physical impairment |
| rs2811712(A;G) | 1.5x less risk for physical impairment |
| rs2811712(A;A) | normal risk |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs2811712(A;A) | 00 | normal risk |
| Rs2811712(A;G) | 1.5x less risk for physical impairment | |
| Rs2811712(G;G) | >1.5x less risk for physical impairment |
rs2811712 is a SNP associated with physical function in older individuals, and thus indirectly associated with longevity.
In a study ultimately totaling over 3,300 elderly Caucasian individuals, the less common rs2811712(G) allele was associated with reduced physical impairment. Overall, severely limited physical function was present in 15.0% of the more common rs2811712(A;A) homozygotes, versus 7.0% of the rs2811712(G;G) homozygotes, yielding a per risk allele odds ratio of 1.48 (CI: 1.17-1.88, p=0.001).[PMID 17459456]
| ? | (A;A) (A;G) (G;G) |
|---|---|
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