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Rs279858

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Orientationminus
is asnp
is mentioned by
dbSNPrs279858
PheGenIrs279858
nextbiors279858
hapmaprs279858
1000 genomesrs279858
hgdprs279858
ensemblrs279858
gopubmedrs279858
geneviewrs279858
scholarrs279858
googlers279858
pharmgkbrs279858
gwascentralrs279858
openSNPrs279858
23andMers279858
23andMe allrs279858
SNP Nexus

SNPshotrs279858
SNPdbers279858
MSV3drs279858
GeneGABRA2
Chromosome4
Orientationminus
GMAF0.4311
Position46312576
ReferenceGRCh38 38.1/141
Max Magnitude2.1
Geno Mag Summary
(A;A) None
(A;G) None
(G;G) 2.1 apparently more prone to alcoholism
? (A;A) (A;G) (G;G) 28

This SNP in the GABRA2 gene has been linked to Alcoholism. The effect of this SNP, a synonymous change at amino acid residue 132, is unknown, but it does not change the GABRA2 protein sequence.

Carriers of at least one rs279858(G) allele respond slower to the effects of alcohol and are thereby apparently more prone to alcoholism than carriers of two rs279858(A) alleles. Finasteride, an FDA approved drug for the treatment of benign prostatic hypertrophy and a modulator of GABRA2, was shown to have more of a blocking effect on rs279858(A) homozygotes. [PMID 15702134]

Note that nearby SNPs have been grouped into a haplotype that shows statistically stronger association with alcohol dependence, namely the haplotype consisting of the rs279871(A) + rs279845(T) + rs279836(A) alleles [PMID 15024690OA-icon.png].

[PMID 18482426] 1050 nicotine-dependent cases and 879 non-dependent smoking controls rs279858 and rs16859834 aka rs2229940


[PMID 22501025OA-icon.png] GABRA2 markers moderate the subjective effects of alcohol


[PMID 16080114OA-icon.png] Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.


[PMID 18005236] Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.


[PMID 18634760OA-icon.png] Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.


[PMID 18727688OA-icon.png] The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.


[PMID 18818659OA-icon.png] GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.


[PMID 19207358OA-icon.png] Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerstrom Test for Nicotine Dependence.


[PMID 19335651OA-icon.png] Candidate genes for cannabis use disorders: findings, challenges and directions.


[PMID 19487630OA-icon.png] Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.


[PMID 20202923OA-icon.png] A genome-wide association study of alcohol dependence.


[PMID 21118274OA-icon.png] Role of GABRA2 in moderating subjective responses to alcohol.


[PMID 21483437OA-icon.png] Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.


[PMID 22978509OA-icon.png] Convergence of Genome-Wide Association and Candidate Gene Studies for Alcoholism


[PMID 24166645] A GABRA2 Variant Is Associated with Increased Stimulation and 'High' Following Alcohol Administration


[PMID 22555154] Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis.


[PMID 24975023] Effect of GABRA2 Genotype on Development of Incentive-Motivation Circuitry in a Sample Enriched for Alcoholism Risk