| Geno
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Mag
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Summary
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| (C;C)
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may be part of a haplotype associated with OCD
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| (C;T)
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may be part of a haplotype associated with OCD
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| (T;T)
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normal
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rs25532 is a SNP in a regulatory region upstream of the serotonin transporter SLC6A4 gene. The more common allele, rs25532(C), is the higher-expressing allele.
A study of patients with obsessive compulsive disorder (OCD) concluded that the major allele of rs25532 was a major contributor to the association of a corresponding haplotype with this disorder. [PMID 18055562]
[PMID 18444253
] Additional functional variation at the SLC6A4 gene.
[PMID 18824000] How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.
[PMID 23510579] Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies.
[PMID 23630162] Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.
] Additional functional variation at the SLC6A4 gene.
