From SNPedia
This SNP, located in an intron of the
GRIK2 gene, has been linked in one study to increased thoughts of
suicide in patients using the anti-depressant drug
citalopram. The risk is only seen for individuals carrying two
rs2518224(C) alleles, i.e. the
rs2518224(C;C) homozygotes. The odds ratio for these individuals is 8.2. If the individual also has at least one
rs4825476(G) allele, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [
PMID 17898344]
| ? | (A;A) (A;C) (C;C) |
|---|
 |
| PharmGKB | PA162263539 |
| Name | |
| Annotation | This SNP in the GRIK2 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped. |
| Gene | GRIK2 |
| Featue | |
| Evidence | PubMed ID:17898344 |
| Drugs | citalopram |
| Diseases | Depression |
| Curation Level | Curated |
