Rs2518224

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is asnp
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dbSNPrs2518224
nextbiors2518224
hapmaprs2518224
1000 genomesrs2518224
hgdprs2518224
ensemblrs2518224
gopubmedrs2518224
scholarrs2518224
googlers2518224
pharmgkbrs2518224
gwascentralrs2518224
openSNPrs2518224
23andMers2518224
23andMe allrs2518224
SNP Nexus

SNPshotrs2518224
SNPdbers2518224
MSV3drs2518224
GeneGRIK2
Chromosome6
Orientationplus
Position101906652
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) 0 normal
(A;C) 0 normal
(C;C)
? (A;A) (A;C) (C;C) 28
This SNP, located in an intron of the GRIK2 gene, has been linked in one study to increased thoughts of suicide in patients using the anti-depressant drug citalopram. The risk is only seen for individuals carrying two rs2518224(C) alleles, i.e. the rs2518224(C;C) homozygotes. The odds ratio for these individuals is 8.2. If the individual also has at least one rs4825476(G) allele, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [PMID 17898344]
PharmGKBPA162263539
Name
AnnotationThis SNP in the GRIK2 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped.
GeneGRIK2
Featue
EvidencePubMed ID:17898344
Drugscitalopram
DiseasesDepression
Curation LevelCurated
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