rs2304016

plus

Geno	Mag	Summary
(A;A)	0	common in complete genomics

Make rs2304016(A;G)

Make rs2304016(G;G)

Reference

GRCh38 38.1/141

Chromosome

2

Position

165311993

Gene

SCN2A

is a	snp
is	mentioned by
dbSNP	rs2304016
dbSNP (classic)	rs2304016
ClinGen	rs2304016
ebi	rs2304016
HLI	rs2304016
Exac	rs2304016
Gnomad	rs2304016
Varsome	rs2304016
LitVar	rs2304016
Map	rs2304016
PheGenI	rs2304016
Biobank	rs2304016
1000 genomes	rs2304016
hgdp	rs2304016
ensembl	rs2304016
geneview	rs2304016
scholar	rs2304016
google	rs2304016
pharmgkb	rs2304016
gwascentral	rs2304016
openSNP	rs2304016
23andMe	rs2304016
SNPshot	rs2304016
SNPdbe	rs2304016
MSV3d	rs2304016
GWAS Ctlg	rs2304016

GMAF

0.03168

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs2304016 (IVS7-32A>G) is a SNP within the SCN2A (sodium channel, voltage-gated, type II, alpha subunit).

[PMID 18784617] among 471 Chinese epilepsy patients (of which 272 were drug responsive and 199 drug resistant), A-allele carriers associated with resistance to anti-epileptic drugs (OR 2.1, 95% CI 1.2-3.7, p=0.007), haplotypes containing A-alleles were also associated w/ drug resistance

[PMID 22569204 ] PharmGKB summary: phenytoin pathway.

[PMID 26189305] ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population

[PMID 30693367] SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.