Rs2250417

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Orientationminus
Make rs2250417(A;A)
Make rs2250417(A;G)
Make rs2250417(G;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position112214593
GeneBCO2
is asnp
is mentioned by
dbSNPrs2250417
PheGenIrs2250417
nextbiors2250417
hapmaprs2250417
1000 genomesrs2250417
hgdprs2250417
ensemblrs2250417
gopubmedrs2250417
geneviewrs2250417
scholarrs2250417
googlers2250417
pharmgkbrs2250417
gwascentralrs2250417
openSNPrs2250417
23andMers2250417
23andMe allrs2250417
SNP Nexus

SNPshotrs2250417
SNPdbers2250417
MSV3drs2250417
GMAF0.3407
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18464913OA-icon.png] Interleukin 18 (IL18) protein levels
GWAS
SNP rs2250417
PubMedID [PMID 18464913OA-icon.png]
Condition Protein quantitative trait loci
Gene IL18
Risk Allele A
pValue 7.00E-013
OR NA
95% CI



[PMID 18853133OA-icon.png] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.


[PMID 19468064OA-icon.png] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.


GET Evidence
rs2250417
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.335938
summary



GWAS snp
PMID [PMID 24182552]
Trait Inflammatory biomarkers
Title Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
Risk Allele T
P-val 2E-32
Odds Ratio .10 [0.08-0.12] unit increase