Rs2241524
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs2241524 |
| hapmap | rs2241524 |
| hgdp | rs2241524 |
| ensembl | rs2241524 |
| gopubmed | rs2241524 |
| scholar | rs2241524 |
| rs2241524 | |
| pharmgkb | rs2241524 |
| hgvbaseg2p | rs2241524 |
| medrefsnp | rs2241524 |
| 23andMe | rs2241524 |
| SNP Nexus |
| Gene | LILRA2 |
| Chromosome | 19 |
| Orientation | minus |
| Position | 59790478 |
| Genotype | Effect |
|---|---|
| rs2241524(C;C) | normal |
| rs2241524(C;T) | normal |
| rs2241524(T;T) | ~2x increased risk for lupus and MPA |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs2241524(C;C) | normal | |
| Rs2241524(C;T) | normal | |
| Rs2241524(T;T) | ~2x increased risk for lupus and MPA |
rs2241524 is a SNP in the LILRA2 gene that disrupts the splice acceptor site of intron 6.
Case-control association studies on 273 Japanese patients with systemic lupus erythematosus (SLE) and 50 patients with microscopic polyangiitis (MPA) showed an association between the homozygous rs2241524(T;T) genotype (as oriented in dbSNP). For the association with SLE, the odds ratio was 1.82 (CI: 1.02-3.24, p=0.041) and for MPA, the odds ratio was 2.52 (CI: 1.07-5.96, p=0.049).[PMID 18273033]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
