Rs216013
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs216013 |
| nextbio | rs216013 |
| hapmap | rs216013 |
| 1000 genomes | rs216013 |
| hgdp | rs216013 |
| ensembl | rs216013 |
| gopubmed | rs216013 |
| scholar | rs216013 |
| rs216013 | |
| pharmgkb | rs216013 |
| gwascentral | rs216013 |
| openSNP | rs216013 |
| 23andMe | rs216013 |
| 23andMe all | rs216013 |
| SNP Nexus | |
| SNPshot | rs216013 |
| SNPdbe | rs216013 |
| MSV3d | rs216013 |
| Gene | CACNA1C |
| Chromosome | 12 |
| Orientation | plus |
| Position | 2729632 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude |
| Make rs216013(A;A) |
| Make rs216013(A;G) |
| Make rs216013(G;G) |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs216013 |
| PubMedID | [PMID 18535201] |
| Condition | Warfarin maintenance dose |
| Gene | CACNA1C |
| Risk Allele | |
| pValue | 9.00E-007 |
| OR | NA |
| 95% CI | |
| PharmGKB | PA165110432 |
| Name | |
| Annotation | This intronic variant in the membrane calcium-channel gene CACNA1C was correlated with warfarin dose (p = 9.2 × 10−5) in the index population (n = 181) from a GWAS study of white patients undergoing anticoagulation therapy. Combined analysis of the index and replication populations (n = 374) yielded a p value of 8.6 × 10−7. "However, this variant did not reach established significance threshold independently in the replication population (P = .002), nor did it achieve significance after multiple testing correction in multivariate modeling (uncorrected P = .003)". |
| Gene | CACNA1C |
| Featue | |
| Evidence | PubMed ID:18535201 |
| Drugs | warfarin |
| Diseases | |
| Curation Level | Curated |
| PharmGKB | PA162356395 |
| Name | |
| Annotation | GWAS results: A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose (Initial Sample Size: 181 individuals; Replication Sample Size: 374 individuals). This variant is associated with Warfarin maintenance dose. |
| Gene | CACNA1C |
| Featue | |
| Evidence | PubMed ID:18535201; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | warfarin |
| Diseases | |
| Curation Level | Non-Curated |
