From SNPedia
rs1975197, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs1975197(T) risk allele is 1.31 (CI: 1.20-1.44, adjusted p = 5 x10e-9). [PMID 18660810]
Note that a nearby SNP, rs4626664, was also shown to independently confer risk for restless legs syndrome in this same study.
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 3
according to
omim 610438. See
also
| PharmGKB | PA162168966 |
| Name | |
| Annotation | A study of 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada identified association of restless legs syndrome (RLS) with this variant in the 5' UTR of PTPRD gene. |
| Gene | PTPRD |
| Featue | |
| Evidence | PubMed ID:18660810 |
| Drugs | |
| Diseases | Restless Legs Syndrome |
| Curation Level | Curated |
