|| 2x increased risk for thyroid cancer
|| 1.5x increased risk for thyroid cancer
, also known as -283G>A, is a SNP upstream of the FOXE1
Based on ~1,000 thyroid cancer patients (and an equal number of controls), a per allele odds ratio of 1.49 (CI: 1.30-1.70, p=5.9x10e-9) was found for the rs1867277(A) allele. This allele is thought to be a causal variant.[PMID 19730683]
[PMID 22282540] Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
[PMID 22493691] Novel associations for hypothyroidism include known autoimmune risk loci.
[PMID 22736773] Association of FOXE1 polyalanine repeat region with papillary thyroid cancer.
[PMID 22882326] FOXE1 polymorphisms are associated with familial and sporadic nonmedullary thyroid cancer susceptibility.
[PMID 23327367] Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry.
[PMID 25849217] Common Variants at 9q22.33, 14q13.3, and ATM Loci, and Risk of Differentiated Thyroid Cancer in the French Polynesian Population
[PMID 25879635] Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population