Rs1867277

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Orientationplus
Geno Mag Summary
(A;A) 2 2x increased risk for thyroid cancer
(A;G) 1.5 1.5x increased risk for thyroid cancer
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome9
Position97853632
GeneFOXE1, RP11-23B15.1
is asnp
is mentioned by
dbSNPrs1867277
PheGenIrs1867277
nextbiors1867277
hapmaprs1867277
1000 genomesrs1867277
hgdprs1867277
ensemblrs1867277
gopubmedrs1867277
geneviewrs1867277
scholarrs1867277
googlers1867277
pharmgkbrs1867277
gwascentralrs1867277
openSNPrs1867277
23andMers1867277
23andMe allrs1867277
SNP Nexus

SNPshotrs1867277
SNPdbers1867277
MSV3drs1867277
GMAF0.3044
Max Magnitude2
rs1867277, also known as -283G>A, is a SNP upstream of the FOXE1 gene.

Based on ~1,000 thyroid cancer patients (and an equal number of controls), a per allele odds ratio of 1.49 (CI: 1.30-1.70, p=5.9x10e-9) was found for the rs1867277(A) allele. This allele is thought to be a causal variant.[PMID 19730683OA-icon.png]


[PMID 22282540OA-icon.png] Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24

[PMID 22493691OA-icon.png] Novel associations for hypothyroidism include known autoimmune risk loci.


[PMID 22736773] Association of FOXE1 polyalanine repeat region with papillary thyroid cancer.


[PMID 22882326] FOXE1 polymorphisms are associated with familial and sporadic nonmedullary thyroid cancer susceptibility.


[PMID 23327367] Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry.