Rs1858830

From SNPedia

rs1858830, located in promoter of the MET gene, has been linked to a 2x increase in the risk of autism based on a study of ~700 families.[PMID 17053076]

From OMIM 164860:

"In case-control analysis, the relative risk for autism was 2.27 for the CC genotype and 1.67 for the GC genotype compared to the GG genotype."

[PMID 19002214] The association of rs1858830 in the MET gene with autism failed to replicate in 325 multiplex families and 10 trios of the International Molecular Genetic Study of Autism Consortium (IMGSAC), although another MET SNP did associate with autism (rs38845)

[PMID 19360663] Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder

[PMID 19548256] Association of MET with social and communication phenotypes in individuals with autism spectrum disorder

[PMID 19681062] Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with Autistic disorder