Rs1801282

From SNPedia

rs1801282, also known as Pro12Ala, is a common SNP in the peroxisome proliferator-activated receptor PPARG gene. The more common (C) allele (in dbSNP orientation) encodes the 'Pro' amino acid at this SNP position.

rs1801282 has been reported to be associated with metabolic syndrome, but other studies have not been able to replicate any strong or significant effect. [PMID 18959602]

[PMID 17554300] The association between type-1 diabetes and SNP rs1801282 is mentioned as being replicated in

[PMID 18280041] rs1801282 and risk of cognitive decline in elders? Maybe with diabetes.

[PMID 19228871] A ten-year study of 679 male patients with symptomatic coronary artery disease found that rs1801282(G) carriers had a much lower (10 year) cardiovascular risk, with the hazard ratio estimated to be 0.10 (CI: 0.01-0.70, p = 0.02) for ischemic heart disease and 0.24 for vascular death (CI: 0.08-0.74, p = 0.013) per copy of the allele.

spittoon carriers could be informed that they really need to watch out for high fat in their diets

Venter snp
Source	plos
Gene	PPARG
allele	G
frequency	0.075
sift
HuRef	1103656026969
Disease Association	Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) (MIM:609338). CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.

GWAS snp
PMID	[PMID 17463246]
Trait	Type 2 diabetes
Title	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele	C
P-val	0.0000019999999999999999
Odds Ratio	1.14 [1.08-1.20]

GWAS snp
PMID	[PMID 17463248]
Trait	Type 2 diabetes
Title	A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Risk Allele	C
P-val	0.0000019999999999999999
Odds Ratio	1.14 [1.08-1.20]

GWAS snp
PMID	[PMID 17463249]
Trait	Type 2 diabetes
Title	Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Risk Allele	C
P-val	0.0000019999999999999999
Odds Ratio	1.14 [1.08-1.20]

[PMID 18972257] Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study

[PMID 18996470] Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes

[PMID 19543210] PPARG Genotype Accounts for Part of Individual Variation in Body Weight Reduction in Response to Calorie Restriction

[PMID 19644638] No association between polymorphisms of proliferator-activated receptor-gamma gene and peak bone mineral density variation in Chinese nuclear families

[PMID 19720797] Impact of The PPAR-{gamma}2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 Diabetes: evidence from Benedict

[PMID 19733160] Gender specific effect of Pro12Ala polymorphism in Peroxisome Proliferator-Activated Receptorgamma-2 gene on obesity risk and leptin levels in a Tunisian population

[PMID 19745552] Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-gamma Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men

[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

[PMID 20179158] The Association Between the Peroxisome Proliferator-Activated Receptor-{gamma}2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis