homozygotes are at 6 fold higher risk compared to (C;C) homozygotes or (C;T) heterozygotes for carotid atherosclerosis [PMID 9514419
]. This polymorphism is known as the "C148-T" variant, and is located in at the "-148" position of the FGB
gene, also known as beta fibrinogen.
[PMID 18726528] A meta-analysis of 7 studies did not find a significant association between the -148C/T FGB SNP and susceptibility to coronary artery disease in Chinese populations.
Note: due to inconsistencies between databases and the literature, the association of this rs# with this polymorphism name as published is highly likely but not guaranteed.
[PMID 20167083] Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study
[PMID 20978265] Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate gene Association Resource (CARe)
[PMID 22386478] Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population
[PMID 18239642] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.
[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
[PMID 20031576] Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
[PMID 23274712] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.