Rs1800787

From SNPedia
Jump to: navigation, search

Orientationplus
Geno Mag Summary
(T;T)
Make rs1800787(C;C)
Make rs1800787(C;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position154562863
GeneFGB
is asnp
is mentioned by
dbSNPrs1800787
Exacrs1800787
PheGenIrs1800787
nextbiors1800787
hapmaprs1800787
1000 genomesrs1800787
hgdprs1800787
ensemblrs1800787
gopubmedrs1800787
geneviewrs1800787
scholarrs1800787
googlers1800787
pharmgkbrs1800787
gwascentralrs1800787
openSNPrs1800787
23andMers1800787
23andMe allrs1800787
SNP Nexus

SNPshotrs1800787
SNPdbers1800787
MSV3drs1800787
GMAF0.1763
Max Magnitude
rs1800787(T;T) homozygotes are at 6 fold higher risk compared to (C;C) homozygotes or (C;T) heterozygotes for carotid atherosclerosis [PMID 9514419]. This polymorphism is known as the "C148-T" variant, and is located in at the "-148" position of the FGB gene, also known as beta fibrinogen.

[PMID 18726528] A meta-analysis of 7 studies did not find a significant association between the -148C/T FGB SNP and susceptibility to coronary artery disease in Chinese populations.

Note: due to inconsistencies between databases and the literature, the association of this rs# with this polymorphism name as published is highly likely but not guaranteed.


[PMID 20167083OA-icon.png] Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study

[PMID 20978265OA-icon.png] Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate gene Association Resource (CARe)


[PMID 22386478] Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population


[PMID 18239642OA-icon.png] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.


[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.


[PMID 20031576OA-icon.png] Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.


[PMID 23274712OA-icon.png] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.