From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal risk
|
| (C;T)
|
|
if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
|
| (T;T)
|
|
if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk
|
rs1799724, a SNP near the tumor necrosis factor
TNF gene, was found in a study of ~500 Caucasians to be both an independent risk factor for the development of
Alzheimer's disease and also a modifier of the risk for individuals carrying
ApoE4 alleles. [
PMID 15895461]
On its own, the rs1799724(T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of ApoE4 alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of rs1799724(T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence. [PMID 15895461]
In a Chinese study [PMID 18551993], post-menopausal women were significantly more likely to have low bone mineral density if they had
[PMID 19282863] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
news cigarette smoking and gastric cancer risk
| PharmGKB | PA161145118 |
| Name | TNF:-850C-T |
| Annotation | Increased risk of vascular dementia and alzeimer's disease for individuals with a CT or TT genotype. |
| Gene | LTA, TNF |
| Featue | |
| Evidence | PubMed ID:11273064 |
| Drugs | |
| Diseases | |
| Curation Level | Curated |
[PMID 20357201] Association of Polymorphisms of Tumor Necrosis Factor and Tumor Protein p53 with Primary Open Angle Glaucoma: A Replication Study of Ten Genes in A Chinese Population
| PharmGKB | PA161145121 |
| Name | TNF:?857 C/T |
| Annotation | Haplotype tagging SNP. |
| Gene | LTA, TNF |
| Featue | |
| Evidence | PubMed ID:17450233 |
| Drugs | |
| Diseases | |
| Curation Level | Curated |
[PMID 21228795] Impact of LIMK1, MMP2 and TNF-? variations for intracranial aneurysm in Japanese population
| ? | (C;C) (C;T) (T;T) | |
|---|
 |
[PMID 21904873] Association of tumor necrosis factor-? (TNF-?) promoter polymorphisms with overweight/obesity in a Korean population
