Rs17884712
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs17884712 |
| hapmap | rs17884712 |
| hgdp | rs17884712 |
| ensembl | rs17884712 |
| gopubmed | rs17884712 |
| scholar | rs17884712 |
| rs17884712 | |
| pharmgkb | rs17884712 |
| hgvbaseg2p | rs17884712 |
| medrefsnp | rs17884712 |
| 23andMe | rs17884712 |
| SNP Nexus |
| Chromosome | 10 |
| Orientation | plus |
| Position | 96525235 |
| Genotype | Effect |
|---|---|
| rs17884712(A;A) | CYP2C19*9 homozygote |
| rs17884712(A;G) | carrier of one CYP2C19*9 allele |
| rs17884712(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs17884712(A;A) | CYP2C19*9 homozygote | |
| Rs17884712(A;G) | carrier of one CYP2C19*9 allele | |
| Rs17884712(G;G) | 00 | normal |
The rs17884712(A) allele defines the CYP2C19 variant known as CYP2C19*9, which is associated with a slight decrease in the metabolism of S-mephenytoin (at least in vitro).[PMID 12464799]
| PharmGKB | PA162355682 |
| Name | CYP2C19:431G>A, R144H |
| Annotation | This variant is the defining SNP for CYP2C19*9 and associated with a modest decrease in the V(max) for 4'-hydroxylation of S-mephenytoin in vitro. |
| Gene | CYP2C19 |
| Featue | Exon/NonSyn |
| Evidence | PubMed ID:12464799 |
| Drugs | mephenytoin |
| Diseases | |
| Curation Level | Curated |
