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rs17672135

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) 1.4 Reduced risk (0.7x) for heart disease
(T;T) 2 1.3x risk
ReferenceGRCh38 38.1/141
Chromosome1
Position240282296
GeneFMN2
is asnp
is mentioned by
dbSNPrs17672135
ebirs17672135
Exacrs17672135
Maprs17672135
PheGenIrs17672135
hapmaprs17672135
1000 genomesrs17672135
hgdprs17672135
ensemblrs17672135
gopubmedrs17672135
geneviewrs17672135
scholarrs17672135
googlers17672135
pharmgkbrs17672135
gwascentralrs17672135
openSNPrs17672135
23andMers17672135
23andMe allrs17672135
SNP Nexus

SNPshotrs17672135
SNPdbers17672135
MSV3drs17672135
GWAS Ctlgrs17672135
GMAF0.1084
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs17672135 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.70 (CI 0.61-0.81), and for homozygotes, 1.32 (CI 0.79-2.22). [PMID 17554300OA-icon.png]

GWAS
SNP rs17672135
PubMedID [PMID 17554300OA-icon.png]
Condition Coronary disease
Gene NR
Risk Allele C
pValue 2.00E-006
OR 1.43
95% CI 1.23-1.64



[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.


[PMID 20017983OA-icon.png] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.


GET Evidence
rs17672135
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.109375
summary