Rs17445836

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Orientationplus
Make rs17445836(A;A)
Make rs17445836(A;G)
Make rs17445836(G;G)
ReferenceGRCh38 38.1/141
Chromosome16
Position85984057
is asnp
is mentioned by
dbSNPrs17445836
Exacrs17445836
PheGenIrs17445836
nextbiors17445836
hapmaprs17445836
1000 genomesrs17445836
hgdprs17445836
ensemblrs17445836
gopubmedrs17445836
geneviewrs17445836
scholarrs17445836
googlers17445836
pharmgkbrs17445836
gwascentralrs17445836
openSNPrs17445836
23andMers17445836
23andMe allrs17445836
SNP Nexus

SNPshotrs17445836
SNPdbers17445836
MSV3drs17445836
GMAF0.1281
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs17445836 is a SNP in the region of the IRF8 gene.

A large study (~5,000 patients) found an increased risk for multiple sclerosis associated with rs17445836; the odds ratio for the minor allele was reported as 0.80 (CI: 0.72-0.89, p=3.73x10(-9)).10.1038/ng.401

GWAS snp
PMID [PMID 19525953OA-icon.png]
Trait Multiple sclerosis
Title Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Risk Allele G
P-val 4E-9
Odds Ratio 1.25 [1.12-1.39]
OMIM126200
Desc
Variant
Relatedalso
[PMID 20405052OA-icon.png] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.


GET Evidence
rs17445836
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.132812
summary



[PMID 23965942] Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis