Rs17445836

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs17445836
PheGenI	rs17445836
nextbio	rs17445836
hapmap	rs17445836
1000 genomes	rs17445836
hgdp	rs17445836
ensembl	rs17445836
gopubmed	rs17445836
geneview	rs17445836
scholar	rs17445836
google	rs17445836
pharmgkb	rs17445836
gwascentral	rs17445836
openSNP	rs17445836
23andMe	rs17445836
23andMe all	rs17445836
SNP Nexus
SNPshot	rs17445836
SNPdbe	rs17445836
MSV3d	rs17445836

Chromosome

16

Orientation

plus

GMAF

0.1287

Position

86017663

Reference

GRCh37 37.1/131

Max Magnitude

Make rs17445836(A;A)

Make rs17445836(A;G)

Make rs17445836(G;G)

?	(A;A) (A;G) (G;G)	28

rs17445836 is a SNP in the region of the IRF8 gene.

A large study (~5,000 patients) found an increased risk for multiple sclerosis associated with rs17445836; the odds ratio for the minor allele was reported as 0.80 (CI: 0.72-0.89, p=3.73x10(-9)).10.1038/ng.401

GWAS snp
PMID	[PMID 19525953]
Trait	Multiple sclerosis
Title	Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Risk Allele	G
P-val	4E-9
Odds Ratio	1.25 [1.12-1.39]

OMIM	126200
Desc
Variant
Related	also

[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

GET Evidence
rs17445836
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.132812
summary