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Rs17145738

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Orientationplus
is asnp
is mentioned by
dbSNPrs17145738
PheGenIrs17145738
nextbiors17145738
hapmaprs17145738
1000 genomesrs17145738
hgdprs17145738
ensemblrs17145738
gopubmedrs17145738
geneviewrs17145738
scholarrs17145738
googlers17145738
pharmgkbrs17145738
gwascentralrs17145738
openSNPrs17145738
23andMers17145738
23andMe allrs17145738
SNP Nexus

SNPshotrs17145738
SNPdbers17145738
MSV3drs17145738
GeneTBL2
Chromosome7
Orientationplus
GMAF0.09688
Position73568544
ReferenceGRCh38 38.1/141
Max Magnitude0
Geno Mag Summary
(C;C) 0 common on affy axiom data
Make rs17145738(C;T)
Make rs17145738(T;T)
? (C;C) (C;T) (T;T) 28
[PMID 18596051] rs17145738 influences severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls
GWAS
SNP rs17145738
PubMedID [PMID 18193043]
Condition Triglycerides
Gene MLXIPL
Risk Allele C
pValue 2.00E-012
OR 8.21
95% CI NR) mg/dl highe


GWAS snp
PMID [PMID 18193044OA-icon.png]
Trait Triglycerides
Title Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Risk Allele T
P-val 7.0000000000000001E-22
Odds Ratio 0.14 [0.25-0.53] % SD lower



[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia



[PMID 21149302OA-icon.png] Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population

GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele T
P-val 1E-9
Odds Ratio 0.5700 None


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19185284OA-icon.png] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19299407OA-icon.png] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.


[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.


[PMID 20017967OA-icon.png] Genome-wide association analyses of North American Rheumatoid Arthritis Consortium and Framingham Heart Study data utilizing genome-wide linkage results.


[PMID 20158509] Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke.


GET Evidence
rs17145738
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.109375
summary



[PMID 24160749OA-icon.png] Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations