Rs16942

This SNP, a variant in the BRCA1 gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer. [PMID 17341484]

For this particular SNP, the risk (minor) allele is (G).

For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry or BRCA1 and BRCA2.

Venter snp
Source	plos
Gene	BRCA1
allele	C
frequency	0.356
sift	TOLERATED
HuRef	1103645327477
Disease Association	Defects in BRCA1 are a cause of genetic susceptibility to ovarian cancer (MIM:113705).

[PMID 21890493] Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers