Rs16847548
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs16847548 |
| hapmap | rs16847548 |
| hgdp | rs16847548 |
| ensembl | rs16847548 |
| gopubmed | rs16847548 |
| scholar | rs16847548 |
| rs16847548 | |
| pharmgkb | rs16847548 |
| hgvbaseg2p | rs16847548 |
| medrefsnp | rs16847548 |
| 23andMe | rs16847548 |
| SNP Nexus |
| Chromosome | 1 |
| Orientation | plus |
| Position | 160301897 |
| Genotype | Effect |
|---|---|
| rs16847548(C;C) | 2.6x increased risk for sudden cardiac death in Caucasians |
| rs16847548(C;T) | 1.3x increased risk for sudden cardiac death in Caucasians |
| rs16847548(T;T) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs16847548(C;C) | 2.52.5 | 2.6x increased risk for sudden cardiac death in Caucasians |
| Rs16847548(C;T) | 1.3x increased risk for sudden cardiac death in Caucasians | |
| Rs16847548(T;T) | normal |
[PMID 19204306] Based on a large study of 19,000+ adults, SNPs rs10494366, rs4657139 and rs16847548 were significantly associated with adjusted QT interval in whites but not in African-Americans. The relative hazard of sudden cardiac death (SCD) associated with each rs16847548(C) allele was 1.31 (CI: 1.10 - 1.56, p=0.002). rs12567209 was also independently associated with SCD in whites (relative hazard 0.57, CI: 0.39 - 0.83, p=0.003).
| ? | (C;C) (C;T) (T;T) |
|---|---|
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