Rs13361189
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs13361189 |
| hapmap | rs13361189 |
| hgdp | rs13361189 |
| ensembl | rs13361189 |
| gopubmed | rs13361189 |
| scholar | rs13361189 |
| rs13361189 | |
| pharmgkb | rs13361189 |
| hgvbaseg2p | rs13361189 |
| medrefsnp | rs13361189 |
| 23andMe | rs13361189 |
| SNP Nexus |
| Chromosome | 5 |
| Orientation | plus |
| Position | 150203580 |
| Genotype | Effect |
|---|---|
| rs13361189(C;C) | 2.6x increased risk for Crohn's disease |
| rs13361189(C;T) | 1.3x increased risk for Crohn's disease |
| rs13361189(T;T) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs13361189(C;C) | 2.62.6 | 2.6x increased risk for Crohn's disease |
| Rs13361189(C;T) | 1.31.3 | 1.3x increased risk for Crohn's disease |
| Rs13361189(T;T) | 00 | normal |
rs13361189 is a SNP in the IRGM gene.
A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]
spittoon Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs13361189 |
| PubMedID | [PMID 17554261] |
| Condition | Crohn's disease |
| Gene | IRGM |
| Risk Allele | |
| pValue | 2.00E-010 |
| OR | 1.38 |
| 95% CI | 1.15-1.66 |
Related to INFLAMMATORY BOWEL DISEASE 19; IBD19
according to omim 612278. See also
Related to IMMUNITY-RELATED GTPase FAMILY, M; IRGM
according to omim 608212. See also
| PharmGKB | PA162356573 |
| Name | |
| Annotation | GWAS results: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: 1,182 cases, 2,024 controls). This variant is associated with Crohn's disease. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17554261; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Crohn Disease |
| Curation Level | Non-Curated |
