Rs13361189
| Orientation | plus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs13361189 |
| PheGenI | rs13361189 |
| nextbio | rs13361189 |
| hapmap | rs13361189 |
| 1000 genomes | rs13361189 |
| hgdp | rs13361189 |
| ensembl | rs13361189 |
| gopubmed | rs13361189 |
| geneview | rs13361189 |
| scholar | rs13361189 |
| rs13361189 | |
| pharmgkb | rs13361189 |
| gwascentral | rs13361189 |
| openSNP | rs13361189 |
| 23andMe | rs13361189 |
| 23andMe all | rs13361189 |
| SNP Nexus | |
| SNPshot | rs13361189 |
| SNPdbe | rs13361189 |
| MSV3d | rs13361189 |
| Chromosome | 5 |
| Orientation | plus |
| GMAF | 0.2743 |
| Position | 150223387 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2.6 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.6 | 2.6x increased risk for Crohn's disease |
| (C;T) | 1.3 | 1.3x increased risk for Crohn's disease |
| (T;T) | 0 | normal |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]
23andMe blog Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T
| GWAS | |
|---|---|
| SNP | rs13361189 |
| PubMedID | [PMID 17554261] |
| Condition | Crohn's disease |
| Gene | IRGM |
| Risk Allele | |
| pValue | 2.00E-010 |
| OR | 1.38 |
| 95% CI | 1.15-1.66 |
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 22713085] IRGM gene polymorphisms and risk of gastric cancer
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18580884] Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 19165925] Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
[PMID 19750224] Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
[PMID 20395867] Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
[PMID 21049557] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
| GET Evidence | |
|---|---|
| rs13361189 | |
| aa_change | |
| aa_change_short | |
| impact | pathogenic |
| qualified_impact | Insufficiently evaluated pathogenic |
| overall_frequency | 0.203704 |
| summary | |
