From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
2.6
|
2.6x increased risk for Crohn's disease
|
| (C;T)
|
1.3
|
1.3x increased risk for Crohn's disease
|
| (T;T)
|
0
|
normal
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
is a SNP in the
IRGM gene.
A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]
spittoon Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T
| OMIM | 612278 |
| Desc | INFLAMMATORY BOWEL DISEASE 19; IBD19 |
| Variant | |
| Related | also |
| OMIM | 608212 |
| Desc | IMMUNITY-RELATED GTPase FAMILY, M; IRGM |
| Variant | |
| Related | also |
| PharmGKB | PA162356573 |
| Name | |
| Annotation | GWAS results: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: 1,182 cases, 2,024 controls). This variant is associated with Crohn's disease. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17554261; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Crohn Disease |
| Curation Level | Non-Curated |
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
