Rs13361189

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Geno Mag Summary
(C;C) 2.6 2.6x increased risk for Crohn's disease
(C;T) 1.3 1.3x increased risk for Crohn's disease
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome5
Position150843825
is asnp
is mentioned by
dbSNPrs13361189
Exacrs13361189
PheGenIrs13361189
nextbiors13361189
hapmaprs13361189
1000 genomesrs13361189
hgdprs13361189
ensemblrs13361189
gopubmedrs13361189
geneviewrs13361189
scholarrs13361189
googlers13361189
pharmgkbrs13361189
gwascentralrs13361189
openSNPrs13361189
23andMers13361189
23andMe allrs13361189
SNP Nexus

SNPshotrs13361189
SNPdbers13361189
MSV3drs13361189
GMAF0.2746
Max Magnitude2.6
? (C;C) (C;T) (T;T) 28
rs13361189 is a SNP in the IRGM gene.

A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]

23andMe blog Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T

GWAS
SNP rs13361189
PubMedID [PMID 17554261OA-icon.png]
Condition Crohn's disease
Gene IRGM
Risk Allele
pValue 2.00E-010
OR 1.38
95% CI 1.15-1.66


OMIM612278
DescINFLAMMATORY BOWEL DISEASE 19; IBD19
Variant
Relatedalso
OMIM608212
DescIMMUNITY-RELATED GTPase FAMILY, M; IRGM
Variant
Relatedalso



[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease


[PMID 22713085] IRGM gene polymorphisms and risk of gastric cancer


[PMID 18438406OA-icon.png] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.


[PMID 18580884] Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.


[PMID 19140132OA-icon.png] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.


[PMID 19165925OA-icon.png] Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.


[PMID 19750224OA-icon.png] Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.


[PMID 20106866OA-icon.png] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.


[PMID 20395867] Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?


[PMID 21049557OA-icon.png] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.


[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.


[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.


GET Evidence
rs13361189
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203704
summary



[PMID 24232856OA-icon.png] Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis


[PMID 24264476] Autophagy Gene Polymorphism is Associated with Susceptibility to Leprosy by Affecting Inflammatory Cytokines


[PMID 22573572] Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).


[PMID 24859836] Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions


[PMID 25009628] IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis