Rs11868035

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is asnp
is mentioned by
dbSNPrs11868035
hapmaprs11868035
hgdprs11868035
ensemblrs11868035
gopubmedrs11868035
scholarrs11868035
googlers11868035
pharmgkbrs11868035
hgvbaseg2prs11868035
medrefsnprs11868035
23andMers11868035
SNP Nexus

GeneLOC100289553
Chromosome17
Orientationplus
Position17715101
ReferenceGRCh37 37.1/131
GenotypeEffect
rs11868035(A;A)1.19x increased risk for T2D
rs11868035(A;G)1.19x increased risk for T2D
rs11868035(G;G)normal


Genotypes Magnitude Summary
Rs11868035(A;A) 1.19x increased risk for T2D
Rs11868035(A;G) 1.19x increased risk for T2D
Rs11868035(G;G) 00 normal
? (A;A) (A;G) (G;G) 28
rs11868035 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, rs11868035(A), in the orientation as in dbSNP. [PMID 18192539]

[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)

[PMID 18936756] rs11868035 is associated with increased risk for schizophrenia in German and Scandinavian samples

Neighborrs2297508
Distance216
PharmGKBPA162355925
Name
AnnotationThis SNP in the SREBF1 gene was strongly associated with schizophrenia in German, Danish and Norwegian samples.
GeneSREBF1, RAI1
Featue
EvidencePubMed ID:18936756
Drugs
DiseasesSchizophrenia
Curation LevelCurated