Rs11868035

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is asnp
is mentioned by
dbSNPrs11868035
hapmaprs11868035
hgdprs11868035
ensemblrs11868035
gopubmedrs11868035
scholarrs11868035
googlers11868035
pharmgkbrs11868035
hgvbaseg2prs11868035
medrefsnprs11868035
23andMers11868035
SNP Nexus

GeneRAI1
Chromosome17
Orientationplus
Position17655825
GenotypeEffect
rs11868035(G;G)normal
rs11868035(A;G)1.19x increased risk for T2D
rs11868035(A;A)1.19x increased risk for T2D


Genotypes Magnitude Summary
Rs11868035(A;A) 1.19x increased risk for T2D
Rs11868035(A;G) 1.19x increased risk for T2D
Rs11868035(G;G) 00 normal

rs11868035 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.19 (CI: 1.07-1.33, p=0.002) for the minor (risk) allele, rs11868035(A), in the orientation as in dbSNP. [PMID 18192539]

[PMID 18692268] type-2 diabetes rs2297508(C) and rs11868035(C)

[PMID 18936756] rs11868035 is associated with increased risk for schizophrenia in German and Scandinavian samples

? (A;A) (A;G) (G;G)
Neighborrs2297508
Distance216
PharmGKBPA162355925
Name
AnnotationThis SNP in the SREBF1 gene was strongly associated with schizophrenia in German, Danish and Norwegian samples.
GeneSREBF1, RAI1
Featue
EvidencePubMed ID:18936756
Drugs
DiseasesSchizophrenia
Curation LevelCurated