From SNPedia
rs11761231 has been reported in a large study to be associated with
rheumatoid arthritis, particularly in females.
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.44 (CI 1.19-1.75), and for homozygotes, 1.64 (CI 1.35-1.99). [PMID 17554300]
[PMID 19116934] The association between rs11761231 and rheumatoid arthritis did not reproduce in a North American population, emphasizing "the need to carefully account for population structure to avoid false-positive disease associations".
| ? | (C;C) (C;T) (T;T) |
|---|
 |
| PharmGKB | PA162356639 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,860 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs11761231-C). This variant is associated with rheumatoid arthritis. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Arthritis, Rheumatoid |
| Curation Level | Non-Curated |
