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Rs11761231

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Orientationplus
Geno Mag Summary
(A;A) 0
(C;C)
(C;T)
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome7
Position131685280
is asnp
is mentioned by
dbSNPrs11761231
PheGenIrs11761231
nextbiors11761231
hapmaprs11761231
1000 genomesrs11761231
hgdprs11761231
ensemblrs11761231
gopubmedrs11761231
geneviewrs11761231
scholarrs11761231
googlers11761231
pharmgkbrs11761231
gwascentralrs11761231
openSNPrs11761231
23andMers11761231
23andMe allrs11761231
SNP Nexus

SNPshotrs11761231
SNPdbers11761231
MSV3drs11761231
GMAF0.4334
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs11761231 has been reported in a large study to be associated with rheumatoid arthritis, particularly in females.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.44 (CI 1.19-1.75), and for homozygotes, 1.64 (CI 1.35-1.99). [PMID 17554300OA-icon.png]

[PMID 19116934OA-icon.png] The association between rs11761231 and rheumatoid arthritis did not reproduce in a North American population, emphasizing "the need to carefully account for population structure to avoid false-positive disease associations".

GWAS
SNP rs11761231
PubMedID [PMID 17554300OA-icon.png]
Condition Rheumatoid arthritis
Gene Intergenic
Risk Allele C
pValue 4.00E-007
OR 1.32
95% CI



[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

[PMID 18794857OA-icon.png] Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

[PMID 19445664OA-icon.png] Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls.

[PMID 20017963OA-icon.png] Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.


GET Evidence
rs11761231
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.679688
summary