Rs1136410

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Orientationminus
Geno Mag Summary
(C;C) 0.80x reduced risk for glioblastoma
(C;T) 0.80x reduced risk for glioblastoma
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome1
Position226367601
GenePARP1
is asnp
is mentioned by
dbSNPrs1136410
Exacrs1136410
PheGenIrs1136410
nextbiors1136410
hapmaprs1136410
1000 genomesrs1136410
hgdprs1136410
ensemblrs1136410
gopubmedrs1136410
geneviewrs1136410
scholarrs1136410
googlers1136410
pharmgkbrs1136410
gwascentralrs1136410
openSNPrs1136410
23andMers1136410
23andMe allrs1136410
SNP Nexus

SNPshotrs1136410
SNPdbers1136410
MSV3drs1136410
GMAF0.2443
? (C;C) (C;T) (T;T) 28
rs1136410, also known as V762A, is a SNP in the PARP1 Poly(ADP-ribose) polymerase-1 gene. The rs1136410(C) allele encodes the less common A (alanine) amino acid at this codon.

A study of 1,000 glioblastoma multiforme cases and 2,000 controls in the US concluded that the PARP1 gene rs1136410(C) allele was associated with a 20% reduction in risk for glioblastoma multiforme (odds ratio 0.80, CI: 0.67-0.95).[PMID 19318434OA-icon.png]

A meta-analysis of 21 studies with 12,027 cancer patients found no significant association overall between rs1136410 and cancer risk, however, in the stratified analyses, rs1136410(C) was associated with an increased risk of cancer among Asian populations (CT + CC vs. TT: odds ratio 1.11, CI: 1.01-1.23, p(heterogeneity) = 0.210), but a decreased risk of cancer (CT + CC vs. TT: odds ratio 0.89, CI: 0.80-1.00, p(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (odds ratio 0.79, CI: 0.69-0.90, p(heterogeneity) = 0.800).[PMID 22127734OA-icon.png]


[PMID 20150366OA-icon.png] DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma


[PMID 21612407] Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2


[PMID 21129811] Associations between polymorphisms in DNA repair genes and TP53 mutations in non-small cell lung cancer


[PMID 16465622OA-icon.png] Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.


[PMID 16857995OA-icon.png] Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.


[PMID 17203305] Genetic variation in the base excision repair pathway and bladder cancer risk.


[PMID 17220334] High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.


[PMID 17267408OA-icon.png] Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.


[PMID 18191955OA-icon.png] Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.


[PMID 18701435OA-icon.png] Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.


[PMID 19124499OA-icon.png] Association and interactions between DNA repair gene polymorphisms and adult glioma.


[PMID 19249341OA-icon.png] Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.


[PMID 19822020OA-icon.png] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.


[PMID 20353610OA-icon.png] Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.


[PMID 20486200] Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.


[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.


[PMID 21420246OA-icon.png] Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.


[PMID 22687647] Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.


GET Evidence
PARP1-V762A
aa_change Val762Ala
aa_change_short V762A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.122885
summary



[PMID 22850545OA-icon.png] Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese


[PMID 23633189OA-icon.png] Involvement of PARP-1 Val762Ala Polymorphism in the Onset of Cervical Cancer in Caucasian Women


[PMID 24500421] Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis


[PMID 23608917OA-icon.png] Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.


[PMID 24853559OA-icon.png] PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies


[PMID 24172093] Polymorphisms in base excision repair genes are associated with endometrial cancer risk among postmenopausal Japanese women


[PMID 25106941] Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia