Rs10513025

From SNPedia

rs10513025 is a SNP located in chromosomal region 5p15, in between the SEMA5A and TAS2R1 genes.

Based on a linkage and association mapping study of 1,031 multiplex autism families, rs10513025 was found to be associated with autism, and the expression of SEMA5A was seen to be reduced in brains from autistic patients. Although this finding was replicated, the authors caution that this SNP explains a very small fraction of the heritability of a complex disorder like autism, presumably due to their finding that the most common allele (present at a frequency of ~96%) is the allele associated with higher risk. The much rarer allele, rs10513025(C), is associated with a 0.55x reduced risk for autism (p=9.6x10e-6).10.1038/nature08490

GWAS snp
PMID	[PMID 19812673]
Trait	Autism
Title	A genome-wide linkage and association scan reveals novel loci for autism
Risk Allele
P-val	3E-7
Odds Ratio	1.81 [NR]