Rs1044498
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1044498 |
| hapmap | rs1044498 |
| hgdp | rs1044498 |
| ensembl | rs1044498 |
| gopubmed | rs1044498 |
| scholar | rs1044498 |
| rs1044498 | |
| pharmgkb | rs1044498 |
| hgvbaseg2p | rs1044498 |
| medrefsnp | rs1044498 |
| 23andMe | rs1044498 |
| SNP Nexus |
| Gene | ENPP1 |
| Chromosome | 6 |
| Orientation | plus |
| Position | 132214060 |
| Genotype | Effect |
|---|---|
| rs1044498(A;A)* | ? |
| rs1044498(A;C)* | ? |
| rs1044498(C;C)* | ? |
- related to INSULIN RESISTANCE, SUSCEPTIBILITY TO according to omim 173335.0006
| ? | (A;A) (A;C) (C;C) |
|---|---|
|
| |
blog ENPP1 harbors a mutation with a derived state known to protect against obesity and type II diabetes27 that is present in 90% of non-Africans but virtually absent in Africans
[PMID 18426862] K121Q (rs1044498) The Q allele of ENPP1 K121Q is associated with hyperglycemia and insulin resistance in whites. increased fasting plasma glucose (FPG), A1C, fasting insulin, and insulin resistance by homeostasis model assessment (HOMA-IR; all P = 0.01-0.006).
[PMID 19399648] Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants
[PMID 19656007] Genetic Variants of the ENPP1/PC-1 Gene Are Associated with Hypertriglyceridemia in Male Subjects
[PMID 20091022] The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention
