Rs1042725

From SNPedia

nature SNP rs1042725 is associated with height (P = 4E-8) in a study involving over 20,000 individuals. The gene harboring this SNP, HMGA2, is a strong biological candidate for having an influence on height, since rare, severe mutations in this gene are known to alter body size in mice and humans.

rs1042725 is estimated to explain approx 0.3% of population variation in height in both adults and children (approx 0.4 cm increased adult height per C allele).

[PMID 19139030] rs1042725 is associated with increased height (0.36 cm 95% IC[0.12-0.61] per C allele, P=0.004). in men rs1042725 may explain 3% of height variability

GWAS
SNP	rs1042725
PubMedID	[PMID 17767157]
Condition	Height
Gene	HMGA2
Risk Allele	C
pValue	6.00E-016
OR	0.4
95% CI	NR) cm per copy in adult heigh

GWAS snp
PMID	[PMID 18391950]
Trait	Height
Title	Identification of ten loci associated with height highlights new biological pathways in human growth
Risk Allele	T
P-val	3.0000000000000003E-20
Odds Ratio	0.48 [0.58-1.09] cm shorter

GWAS snp
PMID	[PMID 18391952]
Trait	Height
Title	Genome-wide association analysis identifies 20 loci that influence adult height
Risk Allele	C
P-val	2.9999999999999998E-18
Odds Ratio	0.05 [0.03-0.08] SD taller - among males

[PMID 19842074] Insights into the Regulation of a Common Variant of HMGA2 Associated with Human Height During Embryonic Development

[PMID 20058197] Insights into the regulation of a common variant of HMGA2 associated with human height during embryonic development