From SNPedia
[
PMID 18281018]
schizophrenia
- 375 case and 812 control subjects
- rs10399805 p = .018 and rs2275351; p = .008.
[PMID 18767121] An attempt to repeat the association between rs10399805 and risk for schizophrenia in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.
[PMID 19106306] rs10399805(T;T) genotype showed a 2.5-fold increase in CHI3L1 mRNA expression in peripheral blood cells than those with (C;C) which is associated with the risk of atopy.
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA162565807 |
| Name | |
| Annotation | In a sample of 375 case and 812 control subjects a significant association of schizophrenia with this SNP (rs10399805) in the promoter region of CHI3L1 was identified. The variant is located at position -247 and disrupts the C/EBP-AML-1 binding site in the gene promoter. The risk allele is predicted to increase CHI3L1 expression. |
| Gene | CHI3L1 |
| Featue | |
| Evidence | PubMed ID:18281018 |
| Drugs | |
| Diseases | Schizophrenia |
| Curation Level | Curated |
[PMID 20051317] The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
