| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
if diabetic, poorer response to rosiglitazone
|
| (C;G)
|
|
if diabetic, better response to rosiglitazone
|
| (G;G)
|
|
if diabetic, better response to rosiglitazone
|
A total of 262 Korean type-2 diabetes patients were treated with 12 weeks of rosiglitazone at 4mg/day and genotyped to reveal that rs10192566(G) allele carriers responded better than (C) carriers. Patients with rs10192566(G) alleles had a larger decrease in fasting plasma glucose, 2-h postprandial glucose, and HbA1c than rs10192566(C;C) homozygotes. None of the other LPIN1 gene SNPs tested were associated with response.[PMID 18693052]
Note: rs11693809, rs10192566, and rs2278513 are in nearly complete linkage disequilibrium (D'>0.958, r(2) >0.882).
