Pre-eclampsia

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Pre-eclampsia is caused by pregnancy-induced hypertension. It is also known as gestational hypertension.

Several SNPs have been described as increasing the risk of developing pre-eclampsia, including:

  • rs5186, in the AGTR1 gene
  • rs4762, in the AGT gene, plus others in AGT
  • rs1799983, in the NOS3 gene
  • rs1982073, in the TGFB1 gene. The rs1982073(T) allele is more common in women who develop pre-eclampsia with severe renal complications. However, it is not associated with overall risk of pre-eclampsia.
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