PTPN22
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | PTPN22 |
| PTPN22 | |
| gopubmed | PTPN22 |
| 23andMe | PTPN22 |
dbSNP 26191
PubMed 26191
SADR 26191
HugeNav 26191
HEFalMp PTPN22
| Chromosome position | Summary | |
|---|---|---|
| Rs2476601 | 114179090114,179,090 | |
| Rs3765598 | 114195985114,195,985 |
SNPs in the PTPN22 gene have been linked to autoimmune diseases.
- The 1858C>T SNP rs2476601 in the PTPN22 gene was found to be associated with (1) juvenile idiopathic arthritis (OR=1.41; P=0.04), (2) an increased risk for rheumatoid arthritis (OR=1.58; P=0.001), and (3) with a slight tendency towards an association with celiac disease (OR=1.35; P=0.08). [PMID 15759012]
- This same SNP, rs2476601, has also been reported to potentially reduce the risk of having Behcet's disease. [PMID 17660222]
- This SNP has also been associated with type-1 diabetes.[PMID 17934143]
