Crohn's disease

From SNPedia

Crohn's disease is one type of inflammatory bowel disease; the Wikipedia article on Crohn's has quite a bit of information.

A recent (2007) large study identified 17 SNPs each showing significant, though relatively small, association with increased risk for Crohn's disease. [PMID 17554300] These SNPs are:

• rs11805303
• rs10210302
• rs9858542
• rs17234657
• rs1000113
• rs10761659
• rs10883365
• rs17221417, in the NOD2 gene
• rs2542151
• rs12037606
• rs6596075, in the IBD5 gene
• rs6908425
• rs9469220
• rs7753394
• rs7807268
• rs6601764
• rs8111071

Other genes with variants associated with Crohn's disease include:

• rs5051, a SNP in the AGT gene

• rs2066844, a SNP in the NOD2 gene
• rs2076756, another SNP in the NOD2 gene

• rs2241880, a SNP in the ATG16L1 gene, reported in numerous recent (2007) studies

• rs11209026, a SNP in the IL23R gene, may minimize the risk of Crohn's disease; three other SNPs in the IL23R gene that increase the risk are:
  • rs1004819
  • rs2201841
  • rs10889677

• rs1800471, in the TGFB1 gene

• Two SNPs in the DEFB1 gene:
  • rs11362
  • rs1800972

• A SNP in the TRAIP gene, linked to two in the MST1R gene:
  • rs1128535, in the TRAIP gene
  • rs2230590, in the MST1R gene
  • rs1062633, in the MST1R gene

• A SNP in the NELL1 gene:
  • rs1793004

• Two SNPs upstream of the PTGER4 gene on ch 5p13.1:
  • rs1992660
  • rs1992662

• A SNP in the ATG16L1 gene:
  • rs2241880

• Two SNPs in the IRGM gene:
  • rs13361189
  • rs4958847

• [1] variations in PHOX2B, NCF4 and ATG16L1